Serophen is indicated in the treatment of ovulatory insufficiency in patients who want to become pregnant, whose partners have adequate spermatozoa and potentially functioning hypothalamic-pituitary ovarian system and adequate endogenous estrogens. Obstacles to achieving this goal should be eliminated or adequately addressed before treatment begins. Serophen administration is indicated only in patients with demonstrated ovulatory dysfunction and in whom the following conditions apply: Demonstration of normal liver function. Physiological signs of normal or near-normal endogenous estrogen (from vaginal smears, endometrial biopsy, urine or serum estrogen analysis, or progesterone bleeding) should be present. Decreased estrogen levels, although less favourable, do not prevent successful treatment. Clomiphene citrate therapy is not effective in patients with primary pituitary or ovarian insufficiency. It cannot replace appropriate therapy for other disorders that lead to ovulation dysfunction, such as thyroid or adrenal gland diseases. Patients with abnormal uterine bleeding should be thoroughly examined before starting clomiphene citrate therapy. Most importantly, tumour lesions have been detected.
To stimulate ovulation, prescribe 50 mg once a day before bedtime, starting with 5 days of the menstrual cycle, for 5 days (in the absence of the cycle - at any time). If there is no effect (ovulation does not develop within 30 days), the dose is increased up to 150 mg/day or the course is lengthened up to 10 days. The exchange rate dose should not exceed 1 g. Development of ovulation is determined by the presence of two-phase basal temperature, the average cyclic increase in LH production, the growth of serum progesterone during the probable medium phase of luteinization or menstrual bleeding of women with amenorrhea. If ovulation occurs and pregnancy does not occur, the same dose should be repeated for the next course of treatment. If menstrual bleeding does not follow after probable ovulation, the possibility of pregnancy should be taken into account, and this possibility should be excluded before a new course of treatment. Men are prescribed 50 mg 1-2 times a day for 3-4 months (systematic sperm control is necessary).
Increases the likelihood of multiple pregnancies. The drug is effective at a sufficient level of endogenous estrogens, is less effective at a low level of estrogens and is almost ineffective at a low concentration of gonadotropic hormones of the pituitary gland. In the course of treatment, it is necessary to constantly monitor the gynecologist, to control the function of the ovaries, vaginal examination, to observe the phenomenon of "pupil". During the treatment period it is necessary to be careful when driving motor vehicles and engaging in other potentially dangerous activities that require increased concentration and rapidity of psychomotor reactions. Antiestrogen of non-steroidal structure, the action of which is caused by specific binding to estrogenic receptors of ovaries and pituitary gland. At a low content of estrogen in the body shows a moderate estrogenic effect, at a high content - antiestrogenic effect. In small doses increases the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation, in large doses inhibits the secretion of gonadotropins. Hestagenic and androgenic activity does not possess.
Is it safe to operate or operate heavy machinery when using this product? If you feel drowsy, dizzy, hypotensive or have a headache when you take a Serophene Tablet, you may want to give up driving a car and heavy industrial equipment. You should give up driving if you are drowsy, dizzy or hypotensive. Doctors recommend not drinking alcohol with such medications, as alcohol significantly increases side effects and drowsiness. Please check your body's response when taking Serophene Tablet. Be sure to consult your doctor for advice, taking into account your body's specifics and general health. Does this medicine (product) cause addiction or addiction? Most drugs are not addictive or addictive. In most cases, the state classifies drugs that can cause addiction as controlled vacation drugs. For example, graph H or X in India and graph II-V in the USA. Please check the information on the package to make sure that the drug is not controlled. Also, do not self-treat or accustom your body to medications without consulting your doctor. Can I stop using this product immediately or do I need to stop using it slowly? Some medications need to be stopped gradually because of the effect of recovery. Be sure to contact your doctor for advice, taking into account your body condition, general health and other medications you are taking.